What is Trazodone?
Trazadone is an antidepressant, which does not belong to any antidepressant group. It is used to treat depression, anxiety, sleep disorders. The drug has also a muscle relaxant and sedative effect. Trazadone has a little effect on noradrenaline and dopamine reuptake, acting primarily on serotonin reuptake. In terms of the effectiveness, this drug is comparable to tricyclic antidepressants, significantly exceeding them in a low quantity of possible side effects.
Trazodone is successful to help you get rid of anxiety, fear, tension, insomnia, and irritability, as well as somatic symptoms, such as a headache, palpitations, myalgia, frequent urination, and sweating. Trazodone is used for sleep disorders. It normalizes physiological structure of sleep with an increase of its duration and depth. The drug helps to return sexual desire and potency, relieves craving for alcohol and is effectively used to treat people with withdrawal symptoms (drugs addiction).
Thus, Trazodone has a high level of safety, it is not addictive, it does not have an anticholinergic effect and does not cause weight gain. Half people taking the drug observe therapeutic effect is 3-7 days of treatment (especially using Trazadone for sleep and relieving anxiety), 25% of people - within 2-4 weeks.
Trazodone has become the most popular antidepressant in the 80s of the last century in US t due to its good tolerability and the hypnotic effect. Studies show that this drug can be used to treat depression in the elderly people, insomnia caused by SSRIs, sleep apnea as well as to treat benzodiazepine abuse. Trazodone was used in clinical practice instead for benzodiazepine and for soothing excited and aggressive patients with dementia; to restore erectile function; to treat alcoholism and chronic pains.
Trazodone is especially effective to treat depression, accompanied by sleep disorders. About 67% taking the drug noted an improvement in sleep quality and its depth. People also got rid of night-time awakenings, as opposed to 13% those, who took the placebo. In addition, the drug has helped to cure insomnia, caused by other antidepressants.
The drug restores the structure of sleep and promotes deep restful sleep without nightmares.
What is Trazodone used for?
Trazodone is prescribed to treat:
- depression: neurotic, endogenous, somatogenic, psychotic, including concomitant increased anxiety. Doctors can prescribe the drug if depression has at least 4 following features: psychomotor retardation or agitation, sleep or appetite disorders, decreased interest in life, lack of sexual interest, slow thinking, fatigue, guilt, suicidal thoughts as well as reduced concentration;
- various phobias;
- benzodiazepine drugs addiction;
- acute alcohol withdrawal syndrome;
- impotence / decreased libido;
- prevention of migraine headaches.
Trazodone for sleep
The use of Trazodone for sleep is probably the most common area for its use in clinical psychopharmacology. The drug increases total sleep time by reducing the number of cases of awakening during the night and shortened REM sleep. Trazodone indirectly mitigates the impact of REM sleep on the human psyche, thus weakening the factor, which is one of the most common causes of depression. Unlike tricyclic antidepressants, Trazodone does not shorten fourth tranquil phase of sleep. Thus, the drug may be used in a treatment of increased anxiety, accompanied by insomnia, caused depressive disorder, due to its favorable sedative and hypnotic effects. Taking into account the effect of Trazodone on sleep, this drug is used (while yet illegally) and to treat non-depressive insomnia, which is most frequently observed in patients with alcohol and drug addiction. The usual dose of Trazodone with its use as a hypnotic drug is from 25 to 150 mg.
Trazodone is also effective to reduce stress and anxiety associated with the condition of general anxiety at doses over 250 mg. Furthermore, Trazodone enhances erectile function. Taking 150-200 mg of Trazodone daily can help you to increase a penis size during erection and maintain it for a longer period of time.
Avoid taking Trazodone in case of hypersensitivity to any component of the drug as well as in case of acute myocardial infarction.
Do not take Trazodone together with alcohol or sleeping pills.
Be cautious taking the drug in case of epilepsy (do not change the dosage abruptly), liver or kidney failure, heart disease (especially in case of angina, conduction defects, atrioventricular block, recent myocardial infarction), hyperthyroidism, urination disorders (prostatic hyperplasia), acute angle-closure glaucoma, increased intraocular pressure.
Stop taking the drug if jaundice has been diagnosed.
The use of antidepressants in patients with schizophrenia or other mental health problems can lead to increased psychotic symptoms and paranoid thoughts. People with manic-depressive psychosis depressive episode can become manic – cancel taking the drug in this case.
It is recommended to have blood analysis, in case of flu-like symptoms, sore throat or fever,
Trazodone may reduce arterial pressure, even causing orthostatic hypotension and syncope. It is recommended to reduce the dosage of antihypertensive drugs used together with Trazodone.
There have been cases of priapism caused by the use of Trazodone. Stop taking the drug immediately if you suspect development of this side effect.
Avoid using the drug until 18 years old (clinical trials showed an increase of suicidal thoughts, suicidal behavior and hostility frequency; long-term studies have not been conducted).
If you are taking Trazodone for depression, it is highly recommended for you to be under constant medical supervision (especially in the first few weeks in the case of dose changes) to prevent possible of suicidal ideas or suicide attempts.
Take Trazodone orally with a glass of water after your meals. You can divide your tablet into three parts. Duration of therapy should be at least a month.
Take 75-150 mg of Trazodone 1 time a day at night before bedtime. The dose can be gradually increased up to 300 mg a day in 2 divided doses. You can continue to increase Trazodone dose up to 600 mg a day in divided doses, if necessary. A gradual increase of dose reduces a risk of side effects.
An initial dosage of elderly or debilitated people is 100 mg 1 time a day at bedtime or in divided doses. The dose can be gradually increased then, depending on clinical conditions. It is recommended to gradually reduce the dose at the end of treatment. There is usually no need for dose adjustment in case of renal failure. Take the drug with caution in case of severe renal insufficiency.
The drug has a little or moderate influence on the ability to drive a car and working mechanical equipment.
What is Trazodone dosage for sleep?
Trazodone is commonly prescribed to treat sleep disorders in doses of 50-100 mg a day before going to bed at night. Antidepressant effect is achieved taking more than 300 mg of Trazodone a day.
Trazodone side effects
You can experience the following possible side effects during treatment with Trazodone:
- aggressive behavior;
- decreased libido;
- withdrawal syndrome;
- serotonin syndrome;
- neuroleptic malignant syndrome;
- decreased visual acuity;
- memory impairment;
- clonic convulsions;
- expressive aphasia;
- change in taste;
- dry mouth;
- abdominal pain;
- intestinal obstruction;
- allergic reactions;
- orthostatic hypotension;
- cardiac arrhythmia;
- premature ventricular contractions;
- ventricular tachycardia;
- ventricular bradycardia;
- abnormal electrocardiogram (prolongation of QT interval);
- abnormal blood test results (including agranulocytosis, thrombocytopenia, eosinophilia, leukopenia, anemia);
- liver function disorders (including jaundice, liver cell damage);
- elevated liver enzymes;
- priapism (stop taking the drug immediately in this case);
- weight loss;
- loss of appetite;
- increased appetite;
- antidiuretic hormone syndrome of inappropriate secretion;
- nasal congestion;
- short breath;
- extremities pain;
- back pain;
- muscle and joint pain;
- flu-like symptoms;
- chest pain;
- suicidal thoughts or suicidal behavior while taking trazodone and within a short period of time after its cancellation.
Symptoms of Trazodone overdose include drowsiness, dizziness, nausea and vomiting, and in severe cases - coma, tachycardia, hypotension, hyponatremia, seizures, loss of consciousness, bradycardia, QT-interval prolongation. Symptoms can develop within 24 hours or later after you took too much of the drug. There is no specific antidote, take activated charcoal and make gastric lavage. However, if you experience overdose symptoms mentioned above, it is better to call the ambulance or contact your doctor.
Pseudoephedrine in combination with Trazodone can cause panic, anxiety, depersonalization.
Taking Trazodone with digoxin may lead to an increased concentration of it in blood and development of cardiac glycoside intoxication.
The drug increases the plasma concentrations of carbamazepine.
The combination of trazodone with lithium salts can cause tremors, neurotoxic effects.
It is not recommended to combine the drug with alcohol as it strengthens the central nervous system depression.
Simultaneous intake of Trazodone with thioridazine leads to increased plasma concentrations of the latter.
Tryptophan in combination with the drug can cause psychosis, hypomania, aversion to food.
There were cases reported about side effects from taking phenytoin and fluoxetine together with Trazodone.
Trifluoperazine and chlorpromazine may exacerbate hypotension.
Trazodone weakens the effects of psychostimulants. Trazodone increases the concentration of phenytoin and digoxin in blood. Do not use Trazodone together with MAO inhibitors.
Can I take Trazodone during pregnancy?
The drug belongs to C category. Animal studies revealed no adverse effects on pregnancy and childbirth, embryo, fetus and newborn. Clinical trials with a limited number of pregnant women did not indicate any side effects while taking Trazodone.
However, take the drug with caution during pregnancy. If the drug is used delivery, it is necessary to ensure medical control over the newborn in terms of possible withdrawal symptoms.
Limited data suggest that the drug penetrates into breast milk. That is why avoid using Trazodone during breastfeeding.
Reviews of Trazodone suggest that all antidepressants should be taken only after consultation with your attending physician. People with exactly adjusted individual dosage are pleased with the result of treatment – normal psychological states, no more anxiety and depression, receding fears. Adverse reactions are no more frequent than it is stated in the drug's prescription label. People often complain about drowsiness, weakness, headache and low blood pressure. Some patients experienced difficulty in waking up in the morning if the tablet was taken at bedtime.
Is trazodone a narcotic?
Is trazodone a controlled substance? It is a very common question at people, who are looking for Trazodone for sleep or as an effective antidepressant. Trazodone is not a narcotic and does belong to a list of controlled substances. However, you need to have a prescription to buy Trazodone online or in physical pharmacy.
Can Trazodone get you high?
Trazodone is an antidepressant, it does not contain narcotic substances and so on. That is why you can't get high off Trazodone as in the case with opiates. You can feel drowsiness, for example, but it will not be like euphoria state like from narcotic drugs. Even if you take a large dosage of this antidepressant, you may finish up in a hospital with an overdose. That is why take Trazodone strictly according your doctor's prescription.
Is Trazodone addictive?
According to the prescription label, Trazodone does not cause addiction. However, people who were taking the drug for a long time and then tried to cancel it noted some withdrawal symptoms, common for most antidepressants. That is why it is recommended to gradually reduce the dosage of antidepressants at the end of treatment.
Does Trazodone cause weight gain?
Weight gain is a common side effect of almost all antidepressants. Trazodone is considered to be a typical antidepressant, not belonging to any group. However, several clinical trials have concluded that Trazodone can cause weight gain during treatment. That is why it is recommended to control your eating habits during the drug intake if you are worried to gain weight.
What is Trazodone generic?
Trazodone is a name for both the drug and its active substance. Thus, a generic name for Trazodone is the same. You can buy Trazodone generic online, which would be much cheaper.
How much does Trazodone cost?
Trazodone price can be different depending, when are you going to purchase it. For example, Trazodone street price is different from its cost in pharmacy, because you need a prescription to buy Trazodone, ever. However, you can order Trazodone generic from an online pharmacy without a prescription. All you need to do is to find a reliable online drugstore to avoid getting fake drugs.