What is Mirtazapine (Remeron)?
Mirtazapine is an antidepressant with tetracyclic structure. It strengthens the central adrenergic and serotonergic transmission.
The drug also shows anxiolytic and sedative effect, therefore mirtazapine is most effective to treat various anxiety depressions. Due to its mild sedative effect, people do not usually have suicidal thoughts during treatment.
What is Mirtazapine (Remeron) is used for?
Mirtazapine is prescribed to treat depressive states (including anhedonia, psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts and mood liability).
Mirtazapine (Remeron) dosage
Effective Mirtazapine dose for adults is 15-45 mg a day. Take your daily dosage 1 time a day, preferably before bedtime. The dosage is gradually increased up to 30-45 mg a day. Antidepressant effect develops gradually, usually after 2-3 weeks of treatment, but treatment should be continued for further 4-6 months. If a positive therapeutic effect is not observed after 4-8 weeks of treatment, there is no sense of taking the drug longer. Consult with your doctor about changing the drug.
Cancel Mirtazapine intake gradually, lowering dosage week by week.
Mirtazapine (Remeron) side effects
Central and peripheral nervous system: drowsiness, confusion, emotional lability, change of mentality, agitation, anxiety, apathy, hallucinations, depersonalization, hostility, mania, seizures, dizziness, vertigo, hypersensitivity, convulsions, tremors, myoclonus, hyperkinesia, hypokinesia.
Hematopoiesis: suppression of blood formation - granulocytopenia, agranulocytosis, neutropenia, eosinophilia, aplastic anemia, and thrombocytopenia.
Metabolism: slight increase in appetite and weight gain;
Cardiovascular system: orthostatic hypotension.
Digestive system: nausea, vomiting, constipation, increased appetite, weight gain, dry mouth, thirst, abdominal pains.
Reproductive system: decrease in libido, dysmenorrhoea.
Other: skin rash, hives, flu syndrome, dyspnea, edema, myalgia, back pain, dysuria.
Avoid taking Mirtazapine (Remeron) in case of kidney or hepatic failure, pregnancy, lactation, hypersensitivity to Mirtazapine.
Children should avoid using Mirtazapine, as there is no sufficient information about its safety and efficiency to use for children.
Can I take Mirtazapine (Remeron) during pregnancy and breastfeeding?
Avoid using Mirtazapine during pregnancy and breastfeeding.
Use Mirtazapine (Remeron) with caution if you have epilepsy, organic brain lesions, kidney or liver failure, acute cardiovascular disease, arterial hypotension, urination disorders, benign prostatic hyperplasia, with angle-closure glaucoma, diabetes.
Mirtazapine can cause increased delusions and hallucinations in people with schizophrenia. When treating a depressive phase of manic-depressive psychosis, this condition may change into a manic phase.
Sudden mirtazapine withdrawal after long-term treatment may cause nausea, headache, deterioration of health.
Stop taking Mirtazapine in case of jaundice.
Avoid using Mirtazapine (Remeron) concurrently with MAO inhibitors and within 2 weeks after their withdrawal.
Withdrawal symptoms are possible, because of addiction to the drug.
Avoid taking alcohol during treatment with Mirtazapine.
Take Mirtazapine with caution, if your activities are connected with the necessity of high concentration and speed of psychomotor reactions.
Mirtazapine (Remeron) interaction
Mirtazapine enhances sedative effect of benzodiazepine drugs if they are used simultaneously.
There is a risk of hypertensive crisis if Mirtazapine is taken together with clonidine.
There were cases of severe psychosis reported when Mirtazapine was used together with levodopa as well as case of hypomania in case concomitant intake with Sertraline.
Simultaneous intake of Mirtazapine and ethanol may increase CNS depression.
Mirtazapine (Remeron) reviews
Various antidepressants are very popular now, especially in women. There are few reviews of mirtazapine because it is not the most popular antidepressants. There are reviews of Remeron brand medication as well as Mirtazapine generic.
However, all those who used the drug note its high efficiency: it has helped to eliminate attacks, accompanied by breathing problems, migraines, dizziness, improved the general condition and helped to get rid of other mental problems.
Users also talk about side effects, which they experienced during treatment, such as severe excitement, sleep disorders, weight gain, blurred vision and pain in liver.
Some patients report that they have not felt any relief after treatment. Although such responses are rare. Usually, people continue treatment despite side effects, because they are satisfied with the high efficiency of mirtazapine.
In any case, regardless of disorder complexity, avoid taking the drug without consulting with your doctor. When you need an assistance to support general mental health condition or to improve your mood, make an appointment with a medical specialist, who can assign you an appropriate treatment.