What is Cymbalta?
Unfortunately, the number of people facing depressions, nervous and psychological disorders only increases every year. It is hard to tell what is the main reason for such unpleasant statistics, but the accelerated lifespan, responsible work, misunderstandings in a family, problems in private life - all this can give impetus to nervous shock, stress or to anxiety or depression.
Cymbalta is a popular medication to treat depression. This antidepressant contains Duloxetine as a main active ingredient. Duloxetine is a combined reuptake inhibitor of norepinephrine and serotonin.
It is a modern drug with a dual mechanism of action, which has proved its effectiveness to treat various types of depression. In addition to its high efficiency, this antidepressant can boast the considerable speed of action. The positive antidepressant effect is usually observed during the first week of treatment. In addition, the drug is characterized by stable action, which allows us to observe the continuous improvements throughout the treatment. Moreover, Cymbalta has a strong analgesic effect, coming within the first two weeks of taking the drug.
Numerous researchers of Duloxetine efficiency to deal with a chronic migraine proved, that the drug can successfully cope with pain and increases pain tolerance. More than a half out of the 46 patients, suffering from a chronic migraine, experienced serious improvement. At the same time, by the end of a three-month course treatment, the mean number of days without a headache (for one month) has increased by approximately 60% and the frequency of migraine attacks decreased by 40%.
Cymbalta also has a little anesthetizing action, which, theoretically, is caused by a decline rate of impulses in the CNS.
What is Cymbalta used for?
Thus, Cymbalta is new highly effective and rather safe antidepressant which, undoubtedly, will take an important place in neurologic practice. It can boast not only anti-depression but also analgesic effect, especially in difficult cases of chronic pain.
Cymbalta is used to treat the major depressive disorder and generalized forms of anxiety disorder.
Cymbalta is also used to treat fibromyalgia and diabetic peripheral neuropathy (with severe pain).
Take Cymbalta pill with a glass of water with or without food. Try to avoid damaging the integrity of a capsule shell.
The best dosage for your is determined to depend on a severity and nature of your disease.
Take 1 capsule of Cymbalta 60mg a day, if you have a major depressive disorder. Some people may require a higher dosage - 1 Cymbalta 60mg pill twice a day.
The maximum recommended dosage is 120 mg of Duloxetine a day. There were no studies of using dosages exceeding 120mg a day.
Take 1 pill of Cymbalta 60mg a day, if you suffer from diabetic neuropathic pain.
The dosage can be increased to one Cymbalta pill of 60mg twice a day (under the supervision of your doctor).
Usually, the positive effect after treatment with Cymbalta develops after 2 months of treatment.
The maximum dosage of Duloxetine is 120 mg a day.
It is usually recommended to take 1 pill of Cymbalta 30mg a day at the beginning of treatment if you suffer from generalized anxiety disorder. You can increase the dosage up to 60mg a day if the clinical effect is insufficient. Your doctor may consider prescribing you even 90mg or 120mg of Cymbalta a day in some cases.
The positive effect of treatment is usually observed after 2-4 weeks of treatment.
Duloxetine dosage adjustment is not required if you have mild or moderate kidney failure.
Duloxetine is not prescribed for people with end-stage renal failure.
Avoid using Cymbalta, if you have hepatobiliary system disorders.
Cymbalta side effects
The following undesirable side effects are possible during treatment with Cymbalta:
Nervous system: agitation, sleep disorders, uneasiness, abnormal orgasm, visions, bruxism, orientation disturbances, suicide thoughts, apathy, aggression, hallucinations, mania. Besides, the appearance of tremor, paresthesias, disorders of attention and memory, changes in taste, lethargy, spasms, extrapyramidal disorder are possible.
Special senses: blurred vision, mydriasis, dry eye, glaucoma, pain, and tinnitus.
Heart and blood vessels: tachycardia, atrial fibrillation, supraventricular arrhythmias, palpitations, hot flashes, loss of consciousness and orthostatic hypotension, labile blood pressure, cold extremities, hypertensive crisis.
Respiratory system: epistaxis, sore throat, yawning, feeling of tightness in the throat.
Digestive system: hyperglycemia, anorexia, constipation, vomiting, dyspepsia, abdominal pain, flatulence, bleeding, gastrointestinal system, belching, gastritis, gastroenteritis, bad breath, blood in the stool.
Liver: acute liver injury, hepatitis, increased liver enzymes, liver failure, jaundice.
Urinary system: urinary retention, dysuria, polyuria, nocturia, slow urine flow, change in urine odor.
Reproductive system: menstrual disorders, erectile dysfunction, delayed ejaculation, uterine bleeding, Galactorrhea, symptoms of menopause, hyperprolactinemia.
Allergic reactions: rash, hyperhidrosis, angioedema, contact dermatitis, rash, photosensitivity, Stevens-Johnson syndrome, anaphylactic shock.
Other: laryngitis, hypothyroidism, deficiency of antidiuretic hormone, hyponatremia, increased risk of bruising, bone pain and muscle spasms and twitching of muscles, lockjaw.
You may also feel chest pain, tingling sensation, feeling of heat, thirst, weakness and gait disturbances.
There were reports of weight gain, increased cholesterol levels during treatment with Cymbalta
Cymbalta withdrawal symptoms
It is recommended to cancel Cymbalta intake gradually, for at least 2 weeks (withdrawal syndrome may develop in case of abrupt cessation of therapy).
Cymbalta withdrawal symptoms list may include nausea, headache, and dizziness, as well as hyperhidrosis, irritability, defecation disorders, tremor, sensitivity and sleep disorders.
Avoid taking Cymbalta, if you have a personal intolerance to Duloxetine or other drug's components.
You should also avoid taking Cymbalta if you have:
- Unstable hypertension (taking into account the risk of hypertensive crisis).
- Impaired renal function.
- Liver disorders.
It is strictly contraindicated to use Duloxetine if you are taking MAO inhibitors (duloxetine is also banned for 2 weeks following completion of therapy with such drugs. You can begin monoamine oxidase inhibitors therapy no earlier than 5 days after completion of Duloxetine treatment).
You should also avoid taking Cymbalta together with fluvoxamine, ciprofloxacin, and enoxacin.
Cymbalta is not used in pediatrics.
Take Cymbalta with caution, if you have the predisposition to suicide (such patients have to be under constant control, because there may be possible attempts of suicide at the beginning of therapy).
Besides, take Cymbalta with caution in case of:
- Epileptic attacks, bipolar disorders, and mania (including in history of disorders).
- An increase of intraocular pressure and danger of acute narrow-angle glaucoma.
- Arterial hypertension, heart pathologies and heart rate disorders.
- An increased risk of hyponatremia.
- If you are taking drugs with hepatotoxic effect.
Avoid driving a car or working with potentially dangerous equipment during treatment with Cymbalta.
Cymbalta and pregnancy
There were no studies of using Duloxetine for pregnant women. That is why it is not recommended for pregnant women to take Cymbalta.
Withdrawal symptoms like tremor, hypotension, increased neuro-reflex irritability, breathing and swallowing disorders can be developed in newborns in case of using Cymbalta during pregnancy.
Newborns may also suffer from epileptic attacks if their mothers took serotonergic drugs during pregnancy.
In case you planned or approaching pregnancy during treatment with Duloxetine, consult with your doctor.
The dosage of Duloxetine getting into breast milk is about 0,14% of the dosage taken by feeding mother. Breastfeeding women should avoid taking Cymbalta.
Cymbalta drug interaction
Drugs metabolized with CYP1A2 do not affect the effectiveness of duloxetine, but taking strong CYP1A2 inhibitors may increase serum levels of duloxetine. Avoid taking Cymbalta together with CYP1A2.
Duloxetine moderately inhibits CYP2D6. You should be careful taking duloxetine with drugs metabolized with CYP2 D6. Take into account the possibility of increasing their plasma levels.
Use Cymbalta with caution together with sedatives and other drugs depressing the central nervous system, including tricyclic antidepressants, tryptophan, and tramadol.
Avoid taking Duloxetine together with MAO inhibitors.
Cymbalta may increase the risk of bleeding during therapy with antithrombotic and anticoagulant substances.
There is limited information about intoxication with duloxetine. There were reports about several cases of taking duloxetine in extremely high dosages around 1400 mg (including cases of the combined intake of other drugs) with a favorable outcome. Most common symptoms of overdose with Duloxetine are epileptic seizures, vomiting, serotonin syndrome, tachycardia, and drowsiness.
If you think you took too much of Cymbalta and experience unpleasant side effects, seek medical help immediately.
Cymbalta reviews are interesting for those, who are going to take this drug. And though everybody reacts to the same drug individually, it can be useful to read reviews of Duloxetine.
There are various reviews of Cymbalta. Some people say this drug causes a lot of side effects. Other people mention withdrawal syndrome, which makes it very hard to give up the drug. On the other hand, many people note the high efficiency of the drug. In particular, Cymbalta helped many people to overcome depression, tearfulness, people begin to enjoy their life. The drug is known to improve the mood and to return the desire to live.
How much does Cymbalta cost?
The price of Cymbalta may vary notably depending on a place where you are going to purchase the drug. Buying Cymbalta online is usually cheaper, than in your local drugstore. You can also buy Cymbalta generic online with no prescription – it is the cheapest way to get the drug.
You can get Cymbalta discount coupon and order the brand drug from an established pharmacy.
Is there a generic for Cymbalta?
Yes, you can buy Cymbalta generic online or at your local drugstore. Usually, generic Cymbalta is called Duloxetine, according to the drug's active ingredient. The cost of generic Cymbalta depends on pills dosages (20mg, 30mg, 60mg) and may vary depending on pharmacy prices.
Can Cymbalta get you high?
Cymbalta belongs to a group of selective serotonin and norepinephrine reuptake inhibitor antidepressants. It is not a narcotic and thus is not a controlled substance. It is used to treat mild to major depressive disorders and anxiety. That is why it is unlikely to get your high even if you take large dosages of the drug. Moreover, using too much of Cymbalta may lead to overdose and serious side effects.
What are Cymbalta side effects in women and in men?
Cymbalta side effects are common for men and women. See the list of possible side effects above.
Cymbalta and weight gain?
Weight gain during treatment with Cymbalta is mostly connected with an increased appetite and consumption more food than before.
Attention! If you are overweight and having unfavorable heredity in terms of cardiovascular disease and diabetes - consult with your doctor about taking Cymbalta for a long time or about switching to another drug.
Does Cymbalta Cause Weight Gain?
Of course, most people want to know, whether they are going to gain weight during treatment with Cymbalta since excessive weight gain is a common side effect of most antidepressants. However, it is hard to say beforehand what effect each particular antidepressant is going to have on you.
Several controlled medical studies showed that more people, who used Cymbalta, even lost their weight. It is impossible to predict the reaction of your body to each antidepressant medication.
If you are afraid of gaining excessive weight during Cymbalta treatment, the best way is to control your eating habits. You will not gain weight if you do not consume excessive calories.
Weight fluctuations are a well-known side effect of the drug. Usually, people experience weight loss because of a poor appetite during treatment. However, there were reports of some people during clinical studies. Contact your doctor and discuss the issue if you experience weight loss or weight gain.
Change of your weight is a common side effect of most antidepressants. You can experience weight loss during treatment with Cymbalta, which is usually caused by a decrease in appetite.
It is difficult to say, what kind of weight fluctuation a person is going to have during treatment with Cymbalta. Contact your doctor to discuss your treatment, if you experience weight loss or weight gain.