What is Citalopram (Celexa)?
Citalopram hydrobromide is used to treat depression. It belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs), which act by changing the activity of serotonin in a human brain. Low level of serotonin is connected with mood swings and symptoms of depression. This group of drugs works great for people with severe forms of depression, though it can also be useful for people with slight and moderate depression. Sometimes doctors prescribe citalopram to treat other disorders, such as panic attacks, eating disorder, menopausal hot flushes, anxiety, and alcoholism.
You can buy Celexa 10mg, 20mg, 40 mg on the market. You can also purchase generic Citalopram 10mg, 20mg and 40mg online with or without prescription.
Citalopram does not contact the majority of receptors and does not affect work of enzymes. It has no notable impact on the cardiovascular system, does not provoke weight gain, does not influence appetite and does not interfere with work of kidneys and liver. The drug does not oppress your cognitive functions and does not cause drowsiness. Besides, it has not been revealed its negative impact on reproductive function.
Citalopram is a fat-soluble substance. Therefore, it is very quickly absorbed by the body and starts acting very fast. Celexa does not cause addiction. It can be combined with a set of other drugs, including analgesics, antihistaminic and anti-hypertensive medicines. An important advantage of this drug is its tolerance by most people of different age. The clear antidepressant effect comes after 2-4 weeks of Citalopram treatment, with the first positive results just after the end of the first week of therapy. According to statistics, Citalopram is beneficial for around 80% of people, who used it to treat depression. Several medical studies have shown that the drug has not only antidepressant effect, but it is also very efficient to treat anxiety. Besides, there are almost no withdrawal symptoms after treatment with Citalopram.
Celexa provides mood improvement, decreases anxiety, fear, and tension, eliminates dysphoria, obsessive-compulsive disorder. The drug practically does not cause sedation.
What Is Celexa (Citalopram) used for?
Celexa (Citalopram) is used to treat:
- Various depressions (endogenous and exogenous);
- Affective (depressive, bipolar, dysthymic) disorders;
- Mixed anxiety and depressive disorders;
- Anxiety and phobic disorders (phobic, panic, obsessive-compulsive, general anxiety, posttraumatic stress disorder);
- Somatiс disorder;
- Psychosomatic disorders with vegetative dysfunction (including vegetative dysfunction of a cardiovascular system, respiratory system, gastrointestinal tract, urinogenital system);
- Vascular dementia with depressive symptoms;
- Depressive disorders in women (premenstrual dysphoria, pregnant women depression, puerperal depression, depression in premenopause);
- Eating disorders (anorexia, bulimia);
- Depressions in case of alcoholism;
- Depressions in elderly people.
Avoid taking Citalopram, if you have an intolerance to its components.
Celexa (Citalopram) Dosage
Take Citalopram tablet one time a day with a glass of water with or without your meal.
The initial dosage for adults is 10-20 mg a day, depending on your health condition and disorder. The dosage can be increased to 60 mg a day if necessary.
People of 65 years are more should take 20 mg of Citalopram a day, and increase the dosage up to 40 mg a day if it is necessary.
These dosages recommendations are for reference only. Visit your doctor to get detailed instruction how to take Citalopram.
Therapy duration (for recurrence prevention) is around 6 months and more.
Celexa (Citalopram) withdrawal symptoms
Avoid sharp termination of treatment. Citalopram dosage has to be decreased gradually within at least 1-2 weeks at the end of treatment in order to avoid withdrawal symptoms. If you experience intolerable symptoms after decreasing the dosage or after the end treatment with Citalopram, you can return to your previous dosage or resume taking the drug. The dosage decline can be continued afterward, but more gradually.
There were reports about suicide thoughts and behavior during treatment with Citalopram and after it.
Cancellation of Citalopram intake (especially sharp) often leads to withdrawal symptoms. Most common symptoms include dizziness, sensitivity disorders (including paraesthesias), sleeping disorders (including sleeplessness and intensive dreams), agitation or anxiety, nausea and/or vomiting, tremor, confusion of consciousness, sweating, headache, diarrhea, emotional instability, irritability, visual disorders. As a rule, these effects are expressed poorly or moderately and pass away rather fast. However, some people can experience more acute forms of these symptoms and for a longer period of time. It is recommended to gradually withdraw the drug at the end of treatment by decreasing its dosage.
Development of hypertensive crisis is possible if Citalopram is taken together with MAO inhibitors. Therefore avoid using Citalopram together with MAO inhibitors and within 14 days after the termination of their intake.
Citalopram inhibits CYP2D6 isoenzyme very little, therefore it does not interact with drugs, which are metabolized by this isoenzyme.
Simultaneous use of Citalopram and Cimetidine can moderately increase concentration of Citalopram in blood plasma.
Citalopram and alcohol
Numerous studies have not detected any interaction between Citalopram and alcohol. Nevertheless, it is recommended to avoid using alcohol during treatment with Citalopram.
Can I take Citalopram during pregnancy and breastfeeding?
The safety using Citalopram during pregnancy and breastfeeding is not established. Treatment with Citalopram is justified only when the potential advantage of therapy for mother exceeds possible risk for fetus and child.
Experimental researches have not revealed teratogenic action and any other influence of Citalopram on reproductive function and on a fetus.
Citalopram side effects
The list of possible side effects during treatment with Citalopram include:
Nervous system: dizzinesses, headache, tremor, drowsiness, sleeplessness, excitement, nervousness, migraine, paresthesias; sleep disorder, disorder of concentration of attention, amnesia, uneasiness, decrease in libido, increase in appetite, anorexia, apathy, suicide attempts, confusion of thoughts, adynamy, mood swings, aggressive behavior, emotional lability, agitation, mania, hypomania, panic behavior, paranoid reaction, psychosis, excessive fatigue, extrapyramidal disorder, spasms, euphoria, agitation, confusion of consciousness, diarrhea, hyperthermia, hyperreflexia, ataxy, increased sweating, uncontrollable behavior, hallucinations, depersonalization;
Convulsive attacks are possible in exceptional cases if the drug is taken in large dosages.
Cardiovascular system: auricular flutter, tachycardia, bradycardia, orthostatic hypotension, increase or decrease in blood pressure, supraventricular and ventricular arrhythmias.
Digestive system: nausea, dry mouth, constipation, diarrhea, dyspepsia, vomiting, meteorism, anorexia, increased salivation, an increase of liver enzymes activity.
Urinary system: frequent urination, polyuria.
Metabolism disorders: weight loss or weight gain, hyponatremia, hyperthermia.
Respiratory system: rhinitis, sinusitis, cough, short wind.
Reproductive system: ejaculation disorders, increase or decrease in libido, female anorgasmia, dysmenorrhea, erectile dysfunction, menstrual cycle disorders, galactorrhoea.
Skin: increased sweating, rash, itch, photosensitivity, epidermal necrolysis, angioedema.
Senses: accommodation disorder, vision or taste disorder, mydriasis.
Musculoskeletal system: myalgia, arthralgia.
Blood coagulant system: rare - bleedings (for example, bleedings caused by gynecologic reasons, gastrointestinal bleedings), thrombocytopenia.
Other: adynamy, fatigue, allergic reactions, syncope, indisposition, mastodynia, yawning, gnash teeth, allergic reactions.
Take minimal dosages of Celexa (Citalopram), if you have liver disorders.
Correction of dosages is not required in case of weak or moderate kidney failure. There is no information concerning using Citalopram for people with heavy kidney failure.
An insignificant decrease in heart rate is possible during treatment with Citalopram, which has no clinical significance. However, Citalopram may cause more expressed bradycardia for people with initially reduced heart rate.
Avoid taking Citalopram with MAO inhibitors.
Take large dosages of Citalopram with caution in case of simultaneous use with Cimetidine
Efficiency and safety of Citalopram to treat children are not established.
Take into an account, that people suffering from depression may experience decreasing in an ability to concentrate attention, which may be aggravated by using psychotropic drugs.
It is recommended to avoid driving a car or working with potentially dangerous mechanisms and machines during treatment with Citalopram, because the ability to concentrate attention decreases, while reaction time increases.
Clinical data about Citalopram overdose are limited and in many cases are connected with the accompanying overdose with other drugs or alcohol. There have been registered cases of Citalopram overdose with lethal outcome. However, the majority of lethal cases has been connected with the accompanying overdose by other medicines.
FDA has published the official report calling doctors and patients to prescribe and use the popular antidepressant Celexa with excessive caution. The drug is capable to sharply break cordial rhythm and cause death if it is taken in large dosages.
The fast rate of modern life is extremely unhealthy for city dwellers: except for cardiovascular diseases, life in the conditions of constant stress also leads to mental disorders. The depression became the real scourge of the large cities, quite often leading to suicides.
Celexa is also one of the most used SSRI medications (Citalopram).
However, as experts from FDA have found out that using high dosages of Celexa exceeding 40 mg a day may lead to fatal outcome. Celexa is capable of causing sharp heart rate disorder, also including also a severe form paroxysmal ventricular tachycardia (torsade de pointes).
Until recently, the instruction for Celexa administration contained information that drug can be used up to 60mg a day for some people.
FDA has published the decision: Forest Pharmaceuticals, Celexa manufacturing company, has to remove the dosage of 60 mg of Celexa a day from the label. A prescription label should also contain prevention addressed to doctors and patients concerning the risk of possible heart side effects during treatment with Celexa.
Celexa (Citalopram) Reviews
Citalopram reviews are mostly positive, people tell about excellent results of treatment when it did not cause side effects. These unpleasant side effects, which are usually rather expressed, did not allow to proceed with treatment. Anyway, only an experienced medical specialist can assess the effect of the drug.
Can Citalopram get you high?
Citalopram can help you to deal with your depression or anxiety. It is not a narcotic substance. That is why you cannot get high off Citalopram. Even if you take a large dosage of the drug, you are going to get only unpleasant side effects, which may even come to lethal consequences.
Does Citalopram cause weight gain?
Like most antidepressants, Citalopram may cause weight gain or weight loss. It is impossible to say in advance will you experience this side effect after treatment with Citalopram or not. There are a lot of factors, which influence possible weight gain, such as dosage, individual factors (metabolism rate, genetics, eating habits, etc), duration of treatment as well as other medications you are taking.
If you start to gain weight after during Citalopram therapy, contact your doctor for more information, how to adjust your treatment course or dosage.